Pathological Changes of Copper Ion Poisoning in Mice

Rundong Zhuang

Abstract


In this study, the clinical manifestations of copper poisoning and the pathological changes of tissues and organs were observed by copper sulfate. The experimental mice were randomly divided into four groups: control group (0 mg / kg), low dose group (50 mg / kg), medium dose group (100 mg / kg), high dose group (200 mg / kg), 6 rats in each group, the test period was 2 weeks. The results showed that the mortality rate in the high dose group was higher than that in the middle dose group and the low dose group. Pathological observation of high-dose group showed hepatic steatosis and granular degeneration, hepatocyte showed honeycomb appearance, low dose group and middle dose group hepatocyte enlargement, cytoplasm filled with red stained fine particles; low dose group In the renal tubular degeneration, renal tubular epithelial cell swelling, so that the lumen becomes smaller or narrow, interstitial telangiectasia, congestion. In the middle dose group, there were obvious degeneration of the renal tubules, and there were many red dye protein in the lumen. Part of the renal tubular wall cell structure was destroyed. High dose group of renal tubular epithelial necrosis, disintegration, fall off in the lumen. The results show that copper poisoning mainly damage the liver, kidney and other tissues and organs, eventually leading to morbidity and even death.

Keywords


Copper poisoning; pathological changes; mice

Full Text:

PDF

References


Wang Changqing, Li Jingai. Song Qian. Breeding pig trace element copper poisoning diagnosis and treatment [J].

Contemporary animal husbandry, 2003, 4 (3): 31-33.

Wang Zongyuan. Animal nutrition metabolic diseases and poisoning [J]. Beijing. China Agricultural Publishing House. 1997, 2

(1): 5-8.

Wang Youming, Wang Xiaolong. Application of high steel to chronic poisoning of livestock and poultry and its infl uence on

environmental ecology [J]. Chinese Journal of Veterinary Medicine. 2005, 37 (6): 36-38.

Liu Lu. Dietary copper supply, state and absorption [P]. Foreign medicine a geographical volume. 1997, 18 (l): 15-20.

[5] Zhu Xiuqin, Zhang De-shou. Clinical pathology of chicken and copper poisoning [J]. Chinese Journal of Veterinary

Science. 2005, 25 (12): 11-16.

Liu Chengwen, Zhang Huaili, Wei Dengshan. Diagnosis of porcine copper poisoning [J]. Chinese Journal of Veterinary

Medicine 2001, 37 (3): 53-54.

Yao Yuanfeng. Pig San with feed additives caused by copper poisoning [J]. Guangxi Animal Husbandry and Veterinary

Medicine .1997.13 (3): 59-63.

Li Jianxi, Wang Xuezhi, Yang Zhiqiang. Eff ects of Molybdenum and Copper on Antioxidant Function in Mice [J]. Chinese

Journal of Veterinary Science, 2004, 22 (11): 11-15.

Cui Hengmin, Chen Huaotao. Experimental observation of duck poisoning in young ducks [J]. China Poultry, 2003, 25 (11):

-10.

Shu Hongliang. Hu Caixi. Broiler chicken copper sulfate poisoning diagnosis report [J]. Jiangxi Journal of Animal Science and

Veterinary Medicine. 2006.10 (4): 58-58.

Yang Yunlin, Wang Handong, Wang Zongyuan. Chronic copper poisoning goat clinical symptoms, blood and liver changes in

observation [J]. China Science and Technology .2007 (3): 24-27.

Xu Shiwen, Chi Yumei. Copper defi ciency and livestock disease Heilongjiang animal husbandry and veterinary [J]. 1998.4 (3):

-41.

[Geng Guixia, Sun Lianhui.Eff ects of adding high copper preparation on the burden of adult chicken [J]. Journal of Northwest

Agricultural University. 1998.26 (1): 51-54.

Duan Xiaopeng, Cao Guangrong. Sheep copper research in the research progress [J]. Foreign veterinary medicine a livestock

and poultry disease .1990.4 (2): 4-6.

Journal of Tianjin Medical University, 2004, 10 (2): 185-187. [J]. Journal of Tianjin Medical University, 2004, 10 (2): 185-187.

[J]. Journal of Tianjin Medical University, 2004, 10 (2): 185-187. [17]. Journal of Tianjin Medical University, 2004, 10 (2):

-187.

Pusillo G. Bronh in sheep [J]. Animal Science Abroad, 2000, 5 (1): 48-49. (In Chinese)

Sargison-ND; Soott-PR. The diagnosis and treatment of chronic copper poisoning in 4-to12-week-old single-suckled calves [J]

.Agriculture-Practice.25.17: 3- 4, 36


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.