Advances in studies on the polymorphism of UGT1A1 gene in neonates with unexplained hyperbilirubinemia

Meiling Hu

doi:10.18282/i-cm.v3i1.166

Meiling Hu

Ariticle ID: 166

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DOI: https://doi.org/10.18282/i-cm.v3i1.166

Keywords: UGT1A1 gene polymorphism, Crigler-Najjar syndrome, Gilbert syndrome, neonatal hyperbilirubinemia

Abstract

Neonatal hyperbilirubinemia is a common clinical symptom in the neonatal period. Severe jaundice can cause neonatal bilirubin encephalopathy. Clinically because severe hyperbilirubinemia more causes, the cause of hemolysis and infection is more common, this also accounted for a certain proportion of unknown reasons. UGT1A1 is a key enzyme for bilirubin metabolism, and unexplained jaundice is associated with a decrease in UGT1A1 activity caused by mutations in UGT1A1 gene, leading to neonatal persistent jaundice. The relationship between neonatal unexplained hyperbilirubinemia and UGT1A1 gene polymorphism was reviewed.

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