Study on the relationship between chronic tonsillitis and early stage of kidney failure

Yuqin Hao


Objective: to investigate whether chronic tonsillitis is associated with early kidney failure; to analysis the reliability of urine microalbumin as a
diagnostic indicator of chronic tonsillitis and early stage of kidney failure; either tonsillectomy is the effective way to prevent complications of chronic tonsillitis
and early kidney failure. Methods: 84 patients with chronic tonsillitis who admitted to the department of Otorhinolaryngology, Qinghai University Affiliated
Hospital from March 2012 to February 2013 were selected as subjects, 33 males and 51 females who aged between 7-55 years. It was divided into three group
according to the course of disease, group A: duration is 1 to 3 years; group B: duration of 3 to 5 years; group C; duration> 5 years; in the immunological laboratory,
12 cases of normal control group were collected, male 7 cases , female 5 cases, aged 7 to 55 years old. The amount of microalbuminuria before and after operation
was determined by turbidimetric method. The collected data were analyzed statistically. Results: There was no significant increase in urine microalbumin compared
group A and control group, P> 0.05, the difference was not statistically significant. Group B and group C were significantly higher than those in the control group (P
<0.05), the difference was statistically significant. The levels of microalbuminuria in group A pre-operation was significantly higher than that of in group C (P
<0.05). The difference was statistically significant. The levels of microalbuminuria in group B were significantly higher than those in group C (P <0.05) during preoperation.
The difference was statistically significant. The levels of microalbuminuria were significantly decreased in group A post-operation compared to the
relatively group pre-operation, P <0.05, the difference was statistically significant. In group B, pre-operative and postoperative comparison, urine microalbumin was
significantly decreased, P <0.05, the difference was statistically significant. The levels of microalbuminuria were significantly decreased in post-operative in group
C than that of its pre-operation, P <0.05, the difference was statistically significant. Conclusion: Patients with chronic tonsillitis can be complicated by early stage of
kidney failure. There is a certain clinical value of urine microalbumin used as a diagnostic indicator of chronic tonsillitis and early kidney failure, and its sensitivity
gradually increased with the progress of disease. The only way to prevent the chronic tonsillitis complicated by early kidney failure is to do tonsillectomy.


words Urine microalbumin; Early kidney failure; Course of disease; Chronic tonsillitis

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Huang Xuanzhao, Wang Ji Bao, Kong Weijia. Practical Otolaryngology

Head and Neck Surgery. Beijing: People's Health Publishing House 2010.322

Zhao Zirong. Systemic and local immunological evaluation of children

with pharyngeal lymphatic ring disease [J]. Chinese Journal of Biochemistry

and Molecular Biology, 2001,17 (1): 1-6.

Kielemovithehl H, Keleti G, Bluestone C, et al. Mierobiology of obsturet

ivetonsillar hypertro-phyand reeur rent tonsillitis. Areho to laryn go Head

Neck Surg, 1989.11 (5): 721.

Khavandi A, Whitaker J, Elkington A, et al. Acute streptococcal

myopericardtis mimicking myocardial infarction. American Journal of

Emergency Medicine 2008 Jun; 26 (5): 638.el-2.

(5) Goto T, Bandoh N, Yoshizaki T, et al. Increase in B-cell-activation factor

(BAFF) and IFN-r productions by tonsilla monnuclear cells stimulated with

deoxycytidyl-deoxyguanosine oligodeoxynucleotids (CpG-ODN) in patients

with igA Nephropathy Clinical Immunology, 2008.126: 260-269.

Abedl-Moula AM, sheriff AA, Sallam SA, et al. PREVALENCE of

rheumatic heart disease among school children in Alexandria, Egypt; a

prospective epidemiological study. J Egypt Public Health Assoc 1998; 73:


Xie Yansheng, Chen Xiangmei. Tonsil and IgA nephropathy pathogenesis

and treatment [J]. Chinese Journal of Nephrology, 2004.20 (4): 300-301.

Luo Zhida, Jiang Guangan, Qiu Weijiang, et al. Diagnosis of early renal

injury several experimental application of the comprehensive application of

Chinese primary medicine, 2002,9 (9): 776-777.

Ran E. Children with tonsil inflammation tonsil surface and internal flora

culture [J]. Foreign Medical ENT, 1989,13 (5): 288.

Huang Tao, Dong Yongqin, Wang Hong, et al. Scattering rate

turbidimetric method and ELISA detection of microalbuminuria application

and evaluation [J] Journal of Clinical Laboratory, 1998.16 (4): 230-231.

Shi Yi Fan. Modern medical series. Concorde endocrine and metabolic

[J]. Beijing Science and Technology Press, 199.13 (8): 1349-1356.

Shen Qilin, Wei Mingjing. Urinary microalbumin [M]. Beijing People's

Medical Publishing House, 2001.91 (6): 129-341

Rudack C, Jorg S, Sachese F. Biologically active neutrophil chemokine

patten in tonsillitis. Clin Exp immunol, 2004.135; 511-518.

Charo IF, Ransohoff RM. The many roles of chemokines andchemokine

receptors in inflammation. New England Journal of Medicine 2006; 354: 610-

Kuki K, Gotoh H, Hayashi M, et al. Immunity of tonsil ang IgA

nephropathy relationship between IgA nephropathy and tonsillitis.Acta

Otolaryngol Suppl 2004: 6-9.

Li L, Huang, Sung SS, et al. The chemokine receptros CCR2and

CX3CR1 mediate monocyte macrophage trafficking in kidney ischemiareperfusion

injury. Kidney Int 2008; 74: 1526-1537.

Lee EY, Chung CH, Khoury CC, et al. Monocyte chemoattractant

protein-1 / CCR2 loop, inducible by TGF- (beta), incteases podocyte motility

and albumin permeability. Am J physiol Renal Physiol 2009.90 (6): 22 -

twenty three.

Uchio K, Sawada K, Manabe N. Experssion of macrophage

metalloelastase (MMP-12) in podocytes of hereditary nephritic mice. Journal

of Veterinary Medical Sciernce 2009; 71: 305.

Tang Lin. MCP-1 and kidney disease [J]. Foreign Medical Urinary

System Volume, 2002.25 (2): 25-26.

Ji Zhenjiang, Zhang Zongying. Urine protein detection in the early

diagnosis of diabetic nephropathy in the significance [J] .New Medicine .30

(20): 616-617.

Pan Jing, Wei Mingjing. Urinary microalbumin research recent [J].

Journal of Clinical Laboratory, 2003.21 (5): 316-317.

Luo Rong, Kong Weijia. Chronic tonsillitis early renal damage [J].

Journal of Clinical Otorhinolaryngology, 2005,19 (15); 683-684.

Ye Changbin. Urinary microalbumin in patients with primary

hypertension early renal damage diagnosis and treatment value [J]. Public

Health, 2012.8 (12); 31-32.

Geng Xianghua. Urine microalbumin detection of early diabetic

nephropathy in clinical analysis of bed analysis [J] .2012,617 (10): 473-474

Chernysheva AD, Kirou KA, Crow MK, et al. T cell proliferation

induced by autologous non-T cells is aresponse to apoptotic cells processed

dendritic cells. [J] Immunol 2002; 169: 1241-1250.

Li Yulin, Xu Guobin, Zhu Lihua. Cystatin C and creatinine in the

evaluation of glomerular filtration function of the comparative study [J]

Chinese Journal of Laboratory Diagnosis, 2001 (5), P (154-156) 22 (14): 874-

Wei Youren, Zhu Lihua, Hou Linpu, et al. Urine microalbumin

determination method and application. Biochemistry and Biophysical

Progress, 1995.22 (6): 169-172.

Wang Wei, Ma Guangquan, Li Bin, et al. Effects of different altitudes on

hemodynamics of migrant youth [J]. Journal of Clinical Military Medicine,

35 (5): 6

DOI: https://doi.org/10.18282/i-cm.v2i1.169

DOI (PDF): https://doi.org/10.18282/i-cm.v2i1.169.g157


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