Pathological Changes of Copper Ion Poisoning in Mice

  • Rundong Zhuang
Keywords: Copper poisoning, pathological changes, mice


In this study, the clinical manifestations of copper poisoning and the pathological changes of tissues and organs were observed by copper sulfate. The experimental mice were randomly divided into four groups: control group (0 mg / kg), low dose group (50 mg / kg), medium dose group (100 mg / kg), high dose group (200 mg / kg), 6 rats in each group, the test period was 2 weeks. The results showed that the mortality rate in the high dose group was higher than that in the middle dose group and the low dose group. Pathological observation of high-dose group showed hepatic steatosis and granular degeneration, hepatocyte showed honeycomb appearance, low dose group and middle dose group hepatocyte enlargement, cytoplasm filled with red stained fine particles; low dose group In the renal tubular degeneration, renal tubular epithelial cell swelling, so that the lumen becomes smaller or narrow, interstitial telangiectasia, congestion. In the middle dose group, there were obvious degeneration of the renal tubules, and there were many red dye protein in the lumen. Part of the renal tubular wall cell structure was destroyed. High dose group of renal tubular epithelial necrosis, disintegration, fall off in the lumen. The results show that copper poisoning mainly damage the liver, kidney and other tissues and organs, eventually leading to morbidity and even death.


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